Domperidone and placebo

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Domperidone and placebo

Posted May 16, 2016 by Admin

Purpose The investigators purposes are to define the prevalence of omeprazole resistance gastroesophageal reflux disease (GERD ) in systemic sclerosis (SSc to compare the efficacy of omeprazole in combination with algycon versus omeprazole in combination with domperidone on the severity of reflux symptoms in omeprazole. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.

Is domperidone useful to improve esophageal peristalsis and esophageal acid clearance in gastroesophageal reflux disease? L. Grande, G. Lacima, E. Ros, I. Legazpi, J.C. Garcia-Valdecasas, J. Fuster, J. Visa, C. Pera (Barcelona) Medical treatment of gastroesophageal reflux disease (GERD ) includes dietary, drug, and tobacco.

24-hour pH-monitoring during ingestion of domperidone or placebo also failed to demonstrate any reduction of esophageal exposure to acid by the drug (table 2). Figure 1. LES pressure increments with domperidone (circles) and placebo (dots).

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Domperidone arrow 1mg

Jan 08, 2001 Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial.

Inclusion criteria: SSc patients who completed the phase 1 study. The subjects were defined as PPI-resistance. The subject must be willing to continue phase 2 study. Exclusion criteria: Pregnancy Present of uncontrolled or severe medical problems Present of active infection Allergic history of alginic acid.

Esophageal motility changes after domperidone administration 15' 30' 45' 60' 90' 120' Amplitude upper - 15.1 - 7.6 - 0.4 0.9 - 13.8 - 4.7 middle 2.5 0.3 - 1.8 - 3.4 - 4.6 18.3 lower - 0.9 - 9.1 - 11.6 - 11.6.

Reflux events recorded for the entire 24-hour were: number of reflux episodes, percent reflux time, number of refluxes longer than 5 min, longest reflux episode, reflux index and esophageal clearance. Table 1.

Clinically diagnosed as GERD and GERD -questionnaire score 3 Must not receive any proton pump inhibitor (PPI) or prokinetic drug within 2 weeks before baseline evaluation Exclusion criteria: Pregnancy or lactation Previous history of gastroesophageal surgery or endoscopic therapy due to severe erosive esophagitis Present.

Data are expressed as percentage over placebo. The results of blind comparison of domperidone and placebo on lower esophageal sphincter pressure, showed that the former induces acute increases of LES pressure (figure 1 but has no effect on parameters of esophageal peristalsis (table I).