Domperidone dosage in mares

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Domperidone dosage in mares

Posted Apr 26, 2016 by Admin

To treat fescue toxicity in horses, the typical dose is 1.1 mg/kg by mouth once a day, starting 10-15 days before the Expected Foaling Date (EFD). Doses may vary in different species, when the drug is given by a different route or concurrently with other. For example, domperidone can interact with azole antifungals (i.e. ketoconazole anticholinergic drugs, macrolide antibiotics, opiods, and other medications as well. Storage Domperidone tablets should be stored in a tight, light-resistant container at room temperature and protected from moisture.

Toxins produced by the fungal endophyte, Neotyphodium coenophialum, that grows in fescue, depress the hormones necessary for normal labor, delivery, and lactation in mares. Domperidone counteracts the effects of the fungal toxins by competitively blocking dopamine receptors.

Domperidone increases prolactin secretion indirectly, by interfering with the action of dopamine, whose action is to decrease the secretion of prolactin by the pituitary gland. Domperidone is generally used for disorders of the gastrointestinal tract (gut) and has not been released in Canada for use.

Max dose domperidone

Some adverse reactions that may occur with the use of domperidone may include galactorrhea and gynecomastia. In horses, premature lactation may be the most common effect with the use of the drug.

An increase in aldosterone and prolactin secretion may also occur. Domperidone should not be administered to animals with a known allergy or hypersensitivity to the drug. Drug interactions are a possibility with the use of domperidone, so the prescribing veterinarian should be informed of all.

In some situations we go as high as 40 mg 4 times a day. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance.

Many mothers take the domperidone for 3 to 8 weeks, but sometimes it is needed longer than that, and sometimes it is impossible for mothers to maintain their milk supply without staying on domperidone.