Detailed drug Information for domperidone. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment.
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Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor.
A single 4 mg intravenous dose of domperidone produced peak TSH levels of 1.9-fold above baseline and peak. domperidone 1 mg/ml, 30 ml suspension. India.
What form(s) does this medication come in? Each white, round, biconvex, film-coated tablet, engraved APO on one side and 10 on the other, contains domperidone maleate equivalent to domperidone 10 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, fumaric acid, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose.Seniors.
Identification Name Domperidone Accession Number DB01184 (APRD 00418) Type. Small Molecule Groups Approved, Investigational, Vet Approved Description. A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Pricing information is supplied for informational purposes only. Patents Not Available Properties State Solid Experimental Properties Source melting point 242.5 C Vanderberk, J., Kennis, L.E.J., Van der Aa, M.J.M.C. and Van Heertum, A.H.M.T.; U.S.
Pharmacodynamics Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Mechanism of action Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant.
And Van Heertum, A.H.M.T.; U.S. Patents 4,066,772; January 3,1978; 4.1 10,333; Augu.
Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located.
(1985) pKa 7.9 EL TAYAR, N ET AL. (1985) Predicted Properties Source Water Solubility 0.0925 mg/mL ALOGPS logP 3.7 ALOGPS logP 2.9 ChemAxon logS -3.7 ALOGPS pKa (Strongest Acidic) 12.52 ChemAxon pKa (Strongest Basic) 7.03 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 3 ChemAxon.
The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure.
Affected organisms Humans and other mammals Pathways Not Available SNP Mediated Effects Not Available SNP Mediated Adverse Drug Reactions Not Available ADMET Predicted ADMET features Property Value Probability Human Intestinal Absorption 0.9967 Blood Brain Barrier 0.8686 Caco-2 permeable - 0.8957 P-glycoprotein substrate Substrate 0.7029 P-glycoprotein.
4, Migrid, Flunarizine, Domperidone, Paracetamol, Medinova Lab, Tablet, View. Price. 5, Mygran, Flunarizine, Domperidone, Paracetamol, Sharing Healthcare.
After taking new medications, watch for new symptoms that could be side-effects. Bring all of your medicines to the doctor with you even over-the-counter drugs and herbal remedies so that your doctor can see everything you are taking and possibly detect conflicts.
Benefits of being on this drug can include relieving symptoms of nausea and vomiting. Listed below are the typical uses of domperidone: In adults, the treatment of feeling sick (nausea) or being sick (vomiting) In children over 12 years and weighing over 35 Kg, the.