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01 Overdose For more information on the management of overdose or unintentional ingestion, contact a poison control center (see Poison Control Center Listing ). Clinical effects of overdose The following effects have been selected on the basis of their potential clinical significance (possible signs and.01 The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)not necessarily inclusive: Those indicating need for medical attention only if they continue or are bothersome Incidence less frequent CNS effects 01.
A majority of these side effects resolve spontaneously during continued therapy or are tolerated. However, more serious or troublesome side effects (e.g., galactorrhea, gynecomastia, or menstrual irregularities) can be dose-related and will respond to lowering the dose or discontinuing therapy.
Anticholinergic drugs (see Appendix II ) (concomitant administration of anticholinergic agents may minimize the effects of domperidone 01 ) Azole antifungals (the main metabolic pathway of domperidone is through CYP3A4; as inhibitors of CYP3A4, azole antifungals can block the metabolism of domperidone, resulting in increased plasma concentrations.
Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. 01 AntiemeticThe antiemetic properties of dopamine are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the.