Domperidone solubility

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Domperidone solubility

Posted Apr 28, 2016 by Admin

Inclusion complex was prepared according to method described by Liu, et al. DPD and the HP-CD (USHP 1) were weighed (1:1 molar ratio) and transferred to beaker containing equivolume mixture alcohol-water, sufficient solvent was added to maintained paste like consistency. CO stretching : 1159.14 cm1, CC stretching : 1633.59 cm1. In all the inclusion complexes the prominent and characteristics peaks of DPD are appeared indicating intactness of drug in complexes. FT-IR Studies of DPD, HP-CD, physical mixture and inclusion complexes.

Sigma-Aldrich offers Sigma-D122, Domperidone for your research needs. solubility, DMSO : 10 mg/mL. 0.1 M HCl: soluble. 0.1 M NaOH: slightly soluble.

How to obtain domperidone

The apparent stability constant was calculated from the initial straight portion of the phase solubility diagram using the Eqn. K 1:1slope/So(1-slope) M -1, where, So is solubility of drug without cyclodextrin, M is molar concentration, K is apparent stability constant and slope is calculated from.

In the prepared inclusion complexes there was a reduction in crystallinity of the drug as compared to pure sample which reflects that the drug is dispersed in the polymer and hence increases in the solubility as compared to pure drug.