Effects metoclopramide and domperidone difference

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Effects metoclopramide and domperidone difference

Posted Apr 28, 2016 by Admin

Diabetic gastroparesis: treatment with domperidone-a double-blind, placebo-controlled trial. Digestion. 1983;27(4 214217. PubMed Horowitz M, Harding PE, Chatterton BE, Collins PJ, Shearman DJ. Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. Abstract Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent.

A significant and dose-related inhibition of ICS (conditioned situation) was obtained with 0.8 and 1.6 mg/kg i.v. domperidone and with 0.125, 0.25 and 0.50 mg/kg i.v. metoclopramide. The ED50 values were 0.79 mg/kg and 0.25 mg/kg respectively.

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Sleep-like patterns were not observed with either compound. In the apomorphine-test in dogs, the ratio between the i.v. ED50 values for antagonism of stereotypy and of emesis was 180 for domperidone and 2.67 for metoclopramide.

Scand J Gastroenterol. 1985 Mar;20(2 150154. PubMed Shindler JS, Finnerty GT, Towlson K, Dolan AL, Davies CL, Parkes JD. Domperidone and levodopa in Parkinson's disease. Br J Clin Pharmacol. 1984 Dec;18(6 959962.

Links to PubMed are also available for Selected References. Selected References These references are in PubMed. This may not be the complete list of references from this article. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS.

And with metoclopramide 0.063, 0.125, 0.25 and 0.50 mg/kg i.v. This increase was due to a decrease in fast frequencies, an increase of slower frequencies and a slight increase of the amplitude.