Role of domperidone in gerd

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Role of domperidone in gerd

Posted Apr 29, 2016 by Admin

Theyre often only used in the most serious cases of GERD. For example, prokinetics might be used to treat people who also have insulin-dependent diabetes, or infants and children with significantly impaired bowel emptying or severe constipation that doesnt respond to other treatments. A double-blind randomised study versus placebo. Scand J Gastroenterol. 1994;4:3004. PubMed 10. Bines JE, Quinlan J, Treves S, Kleinman R, Winter H. Efficacy of domperidone in infants and children with gastroesophageal reflux.

MeSH Terms Cisapride Domperidone/therapeutic use Esophagus/drug effects Esophagus/physiopathology. Gastroesophageal Reflux/drug therapy Gastroesophageal Reflux/physiopathology Gastrointestinal Agents/therapeutic use Histamine H2 Antagonists/therapeutic use. Humans Metoclopramide/therapeutic use Piperidines/therapeutic use Substances Gastrointestinal Agents. Histamine H2 Antagonists Piperidines Domperidone Metoclopramide Cisapride.

6. Cohn RC, O'Loughlin EV, Davidson GP, Moore DJ, Lawrence DM. Cisapride in the control of symptoms in infants with gastroesophageal reflux: a randomised, double-blind, placebo-controlled trial. J Pediatric. 1999;134:28792. PubMed 7.

Domperidone reviews lactation

In the acute management of GERD, cisapride is superior to placebo and has the same efficacy as H2 receptor antagonists (H2RAs) in several clinical trials. It is also effective in maintenance therapy for GERD.

It was once considered as effective in treating GERD as H2 receptor blockers such as famotidine (Pepcid) and ranitidine (Zantac). Cisapride is still often used in veterinary medicine. Metoclopramide Metoclopramide (Reglan) is a prokinetic agent that has been used to treat GERD by improving muscle.

In a healthy human esophagus, swallowing induces primary peristalsis. These are the contractions that move your food down your esophagus and through the rest of your digestive system. In turn, gastroesophageal reflux provokes a second wave of muscular contractions that clears the esophagus, pushing food.

1979;55(Suppl. 1 402. PubMed 12. Sol P, Pelet B. Extrapyramidal reaction due to domperidone. Lancet. 1980;I:802. 13. Shafrir Y, Levy Y. Oculogynic crises due to domperidone therapy. Helv Paediatric Acta. 1985;40:95.