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CONCLUSION : Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medication use, and improving pulmonary function. Why it is prescribed : This combination medication contains a proton pump inhibitor and antidopaminergic agent, prescribed for ulcers, indigestion and acid stomach. When it is not to be taken (Contraindications Contraindicated in patients with rise in prolactin level and hypersensitivity.
AIM: To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux. METHODS : We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice.
Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs daytime and nighttime peak expiratory flow rate (PEFR.
RESULTS : Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4 vs 8.9 nighttime asthma symptom score (19.6 vs 5.4 reflux symptom score (8.7 vs 1.6) and rescue medication use (23.2 vs 3.1).